HLA

Time dependence of dN/dS measures at HLA loci under balancing selection

Here is a link for the poster.

HLA supertype variation across populations: new insights into the role of natural selection in the evolution of HLA-A and HLA-B polymorphisms

© 2015, The Author(s).Supertypes are groups of human leukocyte antigen (HLA) alleles which bind overlapping sets of peptides due to sharing specific residues at the anchor positions—the B and F pockets—of the peptide-binding region (PBR). HLA alleles …

Mapping bias overestimates reference allele frequencies at the HLA genes in the 1000 genomes project phase I data

© 2015 Brandt et al.Next-generation sequencing (NGS) technologies have become the standard for data generation in studies of population genomics, as the 1000 Genomes Project (1000G). However, these techniques are known to be problematic when applied …