precision genomics

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

This week in Journal Club at the Mathieson Lab we discussed the recently published paper by Wang et. al (2020) on the theoretical aspects of the transferability of polygenic risk scores across ancestries.

LDpred2: Better, Faster, Stronger

Today we discussed the new version of LDpred: LDpred2 (preprint here). The preprint is short and technical and does not go through the trouble of explaining the models implemented in LDpred1 and LDpred2, since that has been described in great detail in the original publication.