admixture

Abstract: Polygenic risk scores (PRS) summarise the genetic information spread across several genetic variants into one single number. This number can be used to predict an individual’s phenotype or - more realistically - to place an individual in risk groups according to their PRS.

Here is a link for the poster in pdf format plus an audio guide presented at the TAGC 2020 Conferece.

Polygenic risk scores (PRS) summarize the results of GWAS into a single number that can predict quantitative phenotype or disease risk. One barrier to the use of PRS in clinical practice is that the majority of GWAS come from cohorts of European …

The vast majority of genome-wide association studies (GWAS) are performed in cohorts of European ancestry. Systematic differences in polygenic risk scores (PRS) between European and non-European ancestry populations are believed to be largely …