Polygenic risk scores (PRS) summarize the results of GWAS into a single number that can predict quantitative phenotype or disease risk. One barrier to the use of PRS in clinical practice is that the majority of GWAS come from cohorts of European …
Polygenic risk scores (PRS) can be used to summarize the results of genome-wide association studies (GWAS) into a single number representing the risk of disease. For some traits (for example, cardiovascular disease, breast cancer) PRS allows us to …
The vast majority of genome-wide association studies (GWAS) are performed in cohorts of European ancestry. Systematic differences in polygenic risk scores (PRS) between European and non-European ancestry populations are believed to be largely …