Ancestry Matters: why do polygenic risk scores remain limited to a few?

What drives the reduced prediction accuracy of polygenic scores in non-European individuals?

Abstract: Polygenic risk scores (PRS) summarise the genetic information spread across several genetic variants into one single number. This number can be used to predict an individual’s phenotype or - more realistically - to place an individual in risk groups according to their PRS.

Loss of predictive power of polygenic risk scores in admixed populations

Here is a link for the poster in pdf format plus an audio guide presented at the TAGC 2020 Conferece.

Low transferability of height polygenic risk scores in admixed ancestry populations

Polygenic risk scores (PRS) summarize the results of GWAS into a single number that can predict quantitative phenotype or disease risk. One barrier to the use of PRS in clinical practice is that the majority of GWAS come from cohorts of European …

Polygenic risk scores perform poorly across populations

The vast majority of genome-wide association studies (GWAS) are performed in cohorts of European ancestry. Systematic differences in polygenic risk scores (PRS) between European and non-European ancestry populations are believed to be largely …