Polygenic risk scores (PRS) use the results of genome-wide association studies (GWAS) to predict quantitative phenotypes or disease risk at an individual level. This provides a potential route to the use of genetic data in personalized medical care. …
Investigations on different methods for PRS calculation, the effects of different modelling and pruning approeches, and transferability of PRS across ancestries
Today we discussed the new version of LDpred: LDpred2 (preprint here).
The preprint is short and technical and does not go through the trouble of explaining the models implemented in LDpred1 and LDpred2, since that has been described in great detail in the original publication.
Here is a slide presentation for discussing the LDpred2 preprint. Use freely but please give me attribution by referencing my website and my github. Thank you.